Onderzoek: hoe NMN-suppletie gezonde veroudering en NAD+-niveaus verhoogt

The search for a quick and affordable NAD+ measurement

In this study, researchers developed an innovative NAD+ testing method that uses a bioluminescent sensor based on E. coli. This allows NAD+ levels to be quickly measured with just 5 μL of blood from a finger prick. This new method enables easy and inexpensive monitoring of NAD+ levels without the need for expensive laboratory equipment such as HPLC-MS. Additionally, the bioluminescent sensor offers an accurate and scalable solution for analyzing large numbers of samples.

The power of NMN and sports: boost for NAD+

The study demonstrated that both oral NMN supplements and physical activity cause a significant increase in NAD+ levels in the blood. In a clinical study with two dosages of NMN (500 mg and 1000 mg per day), both dosages were found to significantly increase NAD+ levels, depending on the dose. Additionally, exercise combined with NMN resulted in even higher NAD+ values. These findings suggest that NMN supplements and physical activity can be important ways to promote NAD+ levels and thereby health.

Women, men and NAD+: who has the advantage?

The finger-prick NAD+ measurements revealed that there are clear differences in NAD+ levels between men and women, especially before the age of 50. Men were found to have higher average NAD+ levels than women, but after the age of 50, these differences fade. Additionally, there is a clear age-dependent decline in NAD+ levels, which is more pronounced in men than in women. These differences may play a role in understanding aging processes and the development of personalized anti-aging therapies.

Benefits of NMN supplements

  • Increased NAD+ levels in the blood, which is essential for energy production and healthy aging.
  • Improved response to physical activity, which can contribute to better overall health.
  • The possibility for a personalized approach to aging through regular monitoring of NAD+ levels.

Research conclusions

The study shows that NMN supplements are effective in increasing NAD+ levels and that this increase is enhanced by physical activity. The new, affordable testing method offers opportunities for personalized health therapies focused on NAD+ and aging. The findings support the potential of NMN supplementation as an intervention to counteract aging and improve overall vitality.

Source: https://onlinelibrary.wiley.com/doi/10.1111/acel.13965

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